When, in the judgment of the clinician, the need for dosage reduction, discontinuation, or substitution of alternative antiepileptic medication arises, this should be done gradually. The increased risk of suicidal thoughts or behavior with AEDs was observed as early as one week after starting drug treatment with AEDs and persisted for the duration of treatment assessed. Placebo arm, regardless of causality, were rash 21 percent vs. Connective Tissue System: Coarsening of the facial features, enlargement of the lips, gingival hyperplasia, hypertrichosis, and Peyronie disease. 39 percent of patients in the placebo arm at 48 weeks and 36 percent at 96 weeks. His other laboratory data was: Sodium level 121mEq L, potassium. Nursing Mothers Infant breast feeding is not recommended for women taking this drug because phenytoin appears to be secreted in low concentrations in fejn jistghu jixtru i phenytoin ebda preskrizzjoni human milk.